Molecular diagnostics of lymphoma: aberrations and clinical relevance

The thesis explores how knowledge about specific DNA alterations in follicular lymphoma and diffuse large B-cell lymphoma can be used in patient care. It analysed DNA changes in tumor tissue alongside clinical information from patients at diagnosis and during the disease course. The results indicate that the genetic alterations and the clinical course vary widely and change over time. This complicates the use of such knowledge in clinical practice, for instance in diagnostics, prognosis, and follow-up arrangements. The thesis adds to understanding of this intricate genetic picture and its clinical significance.